In recent years, 3D printing technology and related industries have been in full swing, and even affected the industrial layout and development of global manufacturing. At the same time, China's 3D printing industry has also entered a period of high activity. Bio 3D printing is a unique branch of 3D printing technology. It is a new technology combining 3D printing technology with medical, biological materials and computer technology. It can manufacture artificial implants for patient-specific anatomical structure, physiological functions and treatment needs. Biomedical products such as objects, tissues and medical devices. The rapidity, accuracy, and characteristics of bio-3D printing technology make it a promising application in the medical field. The author will briefly introduce several current application forms of bio 3D printing technology in the medical field:
1. Artificial tissue manufacturing based on biological 3D printing
3D printing of artificial tissue organs includes reconstruction and optimization of tissue and anatomy, cell 3D printing technology, printing tissue organ culture and functional induction. Among them, cell 3D printing technology is the core of current research. Cell 3D printing based on discrete manufacturing and tissue engineering theory is a new technique for locating living cell units and making tissue or organ precursors driven by digital models of tissue and organ anatomy. Cell 3D printing is one of the most advanced research in the field of rapid manufacturing. It is currently the most promising technology for manufacturing artificial organs, and has shown great application value in the fields of life science basic research, clinical medicine and drug development.
Figure 1: 3D printed ear cartilage stent
Second, drug development based on bio-3D printing technology
In the field of drug research and development, high-throughput drug screening technology (HTS) has a low success rate due to the departure from the real system environment in the body. The industry urgently needs to establish a 3D tissue model of the simulated body to achieve high content screening (HCS). Cellular 3D printing technology provides new theories and techniques to solve this problem. The author's research team uses cell 3D printing technology to accurately combine adipose stem cells, endothelium and islet cells in a 3D space to form a model that mimics the metabolic regulation structure in the body, showing high-energy energy metabolism regulation and high-content drug screening. This research shows and proves the great application value of cell 3D printing technology in the field of mechanism research and drug development, especially when combined with other technologies, its role will be further amplified if a 3D system with functional organization and more similar in vivo is constructed. , then will further promote the development of drug screening technology.
Figure 2 Drug Screening for Metabolic Syndrome Based on Biological 3D Printing
Third, personalized medical manufacturing based on bio 3D printing
Bio 3D printing technology can also be applied to the manufacture of personalized medical device manufacturing, and customized medical devices can be customized according to the actual situation of patients to meet the needs of diagnosis and treatment. The patient's body shape and disease status are different. Currently, standard orthopedic stents, surgical guides, prostheses, steel plates and other implanted or non-implantable medical devices can only meet the clinical needs of standard patients, and the remaining patients are not optimal. treatment effect. Therefore, it is very important to personalize the design and processing of tissue restorations and surgical instruments required by patients. Traditional manufacturing methods are difficult to ensure low-cost access to biomedical products that are fully compatible with patients. The combination of medical information technology and biological three-dimensional printing technology can customize personalized medical devices around the patient in a short time and at low cost to achieve the best therapeutic effect. Bio 3D printing technology can be widely used in individualized surgical instruments, pre-operative simulations based on organ models, intraoperative implants and cutting guides, etc., and can also produce a variety of implants that have individualized requirements for shape and function. The digitalization, personalization and networking of the diagnostic surgical treatment process have been realized, which is a fundamental change to the traditional biomedical parts product industry chain.
Figure 3 surgical model, personalized implants, rehabilitation aids, medical equipment, etc.
Xu Mingen, professor, doctoral tutor. Member of the Academic Committee of Hangzhou Electronic Science and Technology University, Director of Bio-Manufacturing Engineering Research Center of Hangzhou Electronic Science and Technology University, Deputy Director of Biomedical Engineering and Instrument Research Institute of Hangzhou University of Electronic Science and Technology, Vice Chairman of China 3D Printing Technology Industry Alliance, Zhejiang Province 3D Printing Vice Chairman of the Technology Industry Alliance, Vice Chairman of the Zhejiang Society of Translational Medicine. He has been engaged in biological 3D printing and regenerative medicine research for more than ten years. He has published more than 40 papers in international journals, and has 6 invention patents and 7 software registration rights.
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